Translate this page into:
Restoring upper-limb function following cervical spinal cord injury: Current practice in the United Kingdom
2 Birmingham Hand Centre, Queen Elizabeth Hospital, Birmingham, United Kingdom
Joseph A Ward
Department of Plastic Surgery, Royal Marsden NHS Foundation Trust, 203 Fulham Road, Chelsea, London, SW3 6JJ
|How to cite this article:|
Ward JA, Power DM. Restoring upper-limb function following cervical spinal cord injury: Current practice in the United Kingdom. J Musculoskelet Surg Res 2019;3:146-151
Objectives: Cervical spinal cord injury (CSCI) is a devastating consequence of trauma that results in disabling loss of upper-limb function. Functional reconstruction through surgical intervention can improve quality of life, reduce long-term care needs, and is highly rated by patients. Internationally, limited information exists on the number of patients eligible for surgical intervention, procedures undertaken, and provision of services. Our objective was to answer these questions to inform service developments in the United Kingdom (UK) and abroad. Methods: A postal questionnaire survey was distributed to the clinical leads of each of the 12 UK and Republic of Ireland spinal cord injury centres (SCICs). Information was requested on the local CSCI caseload, referral of CSCI patients to reconstructive upper-limb services, and surgical procedures undertaken locally during defined periods. Nonresponders were followed up with freedom of information requests. Results: Eleven SCICs responded (response rate: 92%) with a mean of 49.6 any-level CSCI patients admitted annually (>C5: 27.9 patients, C5/6: 18 patients, <C6: 6.5 patients). No SCIC reported referring CSCI patients for nerve transfer or awareness of any peripheral nerve service. Five SCICs stated that they referred CSCI patients for surgery to restore upper-limb function. Conclusions: Surgery to restore upper-limb function following CSCI is still developing in the UK. Provision of services to this small but deserving group varies regionally. Clinical expertise is limited to a handful of SCICs where surgeons perform tendon-related procedures. No SCIC reported undertaking nerve transfer surgery. Assessment of upper-limb function should be a standard of care for functional reconstruction of CSCI with awareness of surgery among health-care professionals and patients raised.
Cervical spinal cord injury (CSCI) is a devastating consequence of trauma that afflicts 1 in every 29 adult major trauma patients resulting in disabling loss of upper- and lower-limb function. Those affected endure reduced life expectancy, altered quality of life, significant morbidity, and long-term dependency., In the United Kingdom (UK) and Republic of Ireland (EIRE), rehabilitation is undertaken within designated spinal cord injury centres (SCICs) where patients receive intensive multidisciplinary rehabilitation led by spinal injury physicians. Rehabilitation aims to transition patients to the greatest practicable level of independent living and minimize long-term care needs.
One of the most effective ways to optimize a patient's independence is to maximize their upper-limb function. The importance of upper-limb function is recognized by patients who rate it above control of sexual, bladder, bowel function, spasticity, and pain.,, Historically, the International Classification for Surgery of the Hand in Tetraplegia has guided the use of tendon transfer, tenodesis, and arthrodesis procedures to restore upper-limb function. However, increasingly, nerve transfers are advocated. Proponents argue that they present greater opportunities for functional gain over tendon transfer with restoration of prehensile grip, less postoperative morbidity, and limited or no sacrifice of donor function. Selective nerve fascicle transfer has been undertaken by a number of surgeons internationally,,,,,,,,,,,,,, and represents a promising adjunct.
As UK-based upper-limb surgeons with peripheral nerve expertise, we wish to develop upper-limb services for CSCI patients but recognize provision faces a number of challenges. These include lack of geographically co-located services (hand surgery and spinal rehabilitation), limited surgical expertise nationally (particularly for nerve transfer), poor awareness of current expertise, and historic professional distance. To address some of these factors and inform future service developments, we undertook a postal survey of designated SCICs within the UK and EIRE. We hypothesised that access to reconstructive upper-limb services, particularly nerve transfer surgery, was limited to specialist centers and varied according to the region.
Materials and Methods
A postal questionnaire was distributed to the clinical lead of each UK and EIRE SCIC [Figure - 1] in early 2015. Respondents were asked to detail the number of new traumatic SCI patients managed between January 1 and December 31, 2014, according to the level of injury, outline the local provision of SCIC upper-limb services, detail surgical interventions undertaken for functional reconstruction locally (including outcomes), and outline local availability of nerve transfer for CSCI [Figure - 2]. Before survey distribution each SCIC was contacted to explain the questionnaire rationale. SCICs that did not respond to the survey were re-contacted with the same questions formulated as a freedom of information (FOI) request.
|Figure 1: The United Kingdom spinal cord injury centers. (1) Glasgow (Queen Elizabeth National Spinal Injuries Unit). (2) Belfast (Musgrave Park Hospital). (3) Dublin, EIRE (National Medical Rehabilitation Centre). (4) Southport (Northwest Regional Spinal Injuries Centre). (5) Oswestry (Midlands Centre for Spinal Injuries). (6) Cardiff (Welsh Spinal Injuries and Neurological Rehabilitation Centre). (7) Middlesbrough (Golden Jubilee Regional Spinal Cord Injury Centre). (8) Wakefield (New Pinderfields Regional Spinal Injuries Centre). (9) Sheffield (Princess Royal Spinal Injuries Centre). (10) Aylesbury (The National Spinal Injuries Centre). (11) Stanmore (Spinal Cord Injuries Centre). (12) Salisbury (Duke of Cornwall Spinal Treatment Centre). Taken from http://www.apparelyzed.com/spinalunits.html (Website now defunct)|
|Figure 2: Survey questions|
Three SCICs responded to the postal questionnaire survey, and further eight SCICs subsequently responded to the FOI requests. No response was received from one centre despite follow-up communication.
Spinal cord injury centre admissions
For the study period, the mean number of any-level SCI and any-level tetraplegic admissions was 85.1 (range: 3–140, 11 centers) and 49.6 (range: 27–84, 9 centers), respectively, per SCIC. The mean number of admissions with a CSCI above C5, at C5/6, and below C6 was 27.9 (range: 10–63, 8 centers), 18 (range: 7–27, 7 centers), and 6.5 (range: 1–17, 7 centers), respectively [Figure - 3]. The American Spinal Injury Association Impairment Scale categories for CSCI patients at admission and discharge are presented in [Figure - 4]. The mean age of CSCI admissions (any-level) was 56.5 years (range: 52–63, 6 centers).
|Figure 4: American Spinal Injury Association Impairment Scale categories at admission and discharge|
Upper-limb services for cervical spinal cord injury patients
Six SCICs reported holding local clinics or referring CSCI patients to specialist upper-limb or hand surgery services. Three SCICs stated that they did not routinely or ever refer CSCI patients and two SCICs did not answer the questions posed [Figure - 5]. Four SCICs reported their outcomes for patients referred to specialist upper-limb or hand surgery services [Figure - 6].
|Figure 5: Availability of upper-limb services for cervical spinal cord injury patients|
|Figure 6: Outcomes for patients referred to specialist upper-limb or hand surgery services by spinal cord injury centers over a 3-year period|
Six SCICs employed outcome measures to assess surgical outcomes [Figure - 7].
|Figure 7: Outcome measures employed by spinal cord injury centers following surgery|
We find that CSCI accounts for nearly 60% of all admissions to the UK SCICs, with 50% of admissions representing C5–C8 level injuries. Comparative data relating to UK SCI incidence is difficult to obtain with no published national data currently available. This may change with the advent of the UK National Spinal Cord Injury Database (www.spinalcordinjury.nhs.uk). The high response rate (91.7%) of our survey means a snapshot assessment of annual CSCI workload can be extrapolated based on centre-reported response. We calculate annually that 596 patients within the UK and EIRE sustain an any-level CSCI and reach a SCIC including 294 C5–C8 injuries with varying levels of upper-limb function.
Following a CSCI, it is essential that every patient should have a detailed functional assessment of their upper limb by a specialist upper-limb surgeon; our survey shows that this does not currently occur. Upper-limb examination post-CSCI should not be an isolated event and should be repeated regularly by specialist physiotherapists during inpatient and outpatient follow-up. We strongly recommend that repeated documented clinical examination of the upper limb in CSCI should be integrated into the NHS commissioning criteria for SCICs. This change would improve rehabilitative practice by documenting the course of upper-limb recovery, elucidating surgical candidates, and focusing finite clinical resources on this important functional area. Mandating assessment by an upper-limb surgeon also provides scope for any appropriate surgical strategies (nerve transfers, tendon transfers, etc.) to be explored, discussed and considered by patients.
Our survey suggests that access to upper-limb surgery services following CSCI varies significantly with 25% of SCICs not offering any access – a concerning health-care inequality. Larger SCICs provide greater availability and hold specialist consultant-led clinics but this is very much dependent on a motivated surgeon locally. Confirmatory evidence is available from a recent British Society for Surgery of the Hand survey that identified only ten self-reporting hand surgeons undertaking upper-limb reconstruction for CSCI patients with only two having undertaken more than five cases annually. Just four SCICs reported outcomes for patients who underwent reconstructive upper-limb surgery with tendon-related procedures mainly transfers being the mainstay intervention. No centres reported undertaking nerve transfer procedures – an unsurprising finding when expertise in peripheral nerve surgery is concentrated in specialist centres.
In light of the low number of patients and few SCICs that reported referral outcomes, it is difficult to draw conclusions regarding national practices, but it is clear that procedures performed varied between centers. The survey did not elucidate data on how patients were selected for surgery and the functional gains prioritized, but the recent publication of the International Federation of Societies for Surgery of the Hand Scientific Committee on Nerve–Spinal Cord Injury Report – “Update on Hand Surgery in Tetraplegia” – represents a useful guide for clinical assessment of CSCI patients. The document assists in surgical planning and goal prioritization making recommendations for interventional procedures (but excludes nerve transfer). We recommend that any surgeons asked to assess CSCI patients use this document to formulate treatment recommendations while being conscious of nerve transfer options. Those surgeons with an interest in nerve transfer should seek specialist training to increase exposure in addition to the current hand surgery curriculum.
Surgical uptake varied from 13% to 100% between centres. This is likely to represent variation in service access, surgical expertise, and depth and degree of counseling provided to patients regarding risks and gains of surgery. The decision for any CSCI patient to undergo reconstructive upper-limb surgery is highly influenced by how information is framed by health-care professionals. In similarity to the US, UK health professionals have intrinsic biases. At least one US questionnaire survey has documented discordance between professional groups (surgeons and physicians) on the utility of surgery. When asked whether “functional gains were worth the risk of surgery,” 73% of spinal rehabilitation professionals agreed or strongly agreed compared to 94% of surgeons. When asked whether they “would want upper-extremity surgery,” 93% of spinal rehabilitation consultants agreed compared to 96% of surgeons. Pertinently, the study showed that spinal rehabilitation professionals were much more likely to favor reconstructive upper-limb surgery making 2.8-times more referrals with 13.1 more reconstructions undertaken where good relationships with their local hand surgeon existed., This clearly demonstrates the importance of delivering reconstructive upper-limb surgery for CSCI within the confines of a spinal injury multidisciplinary team (MDT) and good working relationships.
There is a scope for the development of reconstructive upper-limb surgery services, particularly nerve transfer within the UK, and it is hoped that this will act as a blueprint for service developments internationally. It is evident that upper-limb surgeons and spinal rehabilitation professionals need to work together and ensure that access does not vary geographically. This should aim to ensure that every CSCI patient receives an assessment of upper-limb function by an upper-limb surgeon working within a spinal injury MDT. Due to the limited number of upper-limb surgeons with expertise in peripheral nerve surgery, it is not pragmatic for all CSCI patients to be assessed by a peripheral nerve surgeon. Nonetheless, where such surgery may be beneficial, suitable patients should be referred for further assessment. We would encourage all hand surgeons to work with their local SCIC to raise awareness of the potential for reconstructive upper-limb surgery, in particular nerve transfer, for this small but very deserving patient group so that opportunities to improve functional outcomes are not missed.
- All CSCI patients should have a detailed clinical examination of their upper-limb function by a specialist upper-limb surgeon within a year of injury
- Clinical examination of the upper limb in CSCI patients should be integrated into the commissioning criteria for SCICs and regularly repeated
- All SCICs should offer CSCI patients access to upper-limb services that can perform tendon or nerve transfer procedures
- Upper-limb surgeons with an interest in nerve transfer should seek specialist training in CSCI to supplement the current hand surgery curriculum
- All upper-limb surgery following CSCI should be undertaken within the confines of a spinal injury. Patients should be counseled carefully, honestly, and with equipoise.
Ethical approval not sought.
We acknowledge administrative support provided by Sarah Wilson.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
DMP and JAW conceived the study. JAW drafted the questionnaire and collected and analyzed the data generated. JAW wrote and revised the manuscript in conjunction with DMP. DMP and JAW both agreed the final manuscript. All authors have critically reviewed and approved the final draft and are responsible for the content and similarity index of the manuscript.
Hasler RM, Exadaktylos AK, Bouamra O, Benneker LM, Clancy M, Sieber R, et al. Epidemiology and predictors of cervical spine injury in adult major trauma patients: A multicenter cohort study. J Trauma Acute Care Surg 2012;72:975-81.[Google Scholar]
Anderson KD, Fridén J, Lieber RL. Acceptable benefits and risks associated with surgically improving arm function in individuals living with cervical spinal cord injury. Spinal Cord 2009;47:334-8.[Google Scholar]
Sezer N, Akkuş S, Uǧurlu FG. Chronic complications of spinal cord injury. World J Orthop 2015;6:24-33.[Google Scholar]
Anderson KD. Targeting recovery: Priorities of the spinal cord-injured population. J Neurotrauma 2004;21:1371-83.[Google Scholar]
Snoek GJ, IJzerman MJ, Hermens HJ, Maxwell D, Biering-Sorensen F. Survey of the needs of patients with spinal cord injury: Impact and priority for improvement in hand function in tetraplegics. Spinal Cord 2004;42:526-32.[Google Scholar]
Hanson RW, Franklin MR. Sexual loss in relation to other functional losses for spinal cord injured males. Arch Phys Med Rehabil 1976;57:291-3.[Google Scholar]
Moberg E, McDowell CL, House JH. Third international conference on surgical rehabilitation of the upper limb in tetraplegia (quadriplegia). J Hand Surg Am 1989;14:1064-6.[Google Scholar]
Senjaya F, Midha R. Nerve transfer strategies for spinal cord injury. World Neurosurg 2013;80:e319-26.[Google Scholar]
Benassy J. A case of transposition of the musculo-cutaneous nerve upon the median nerve. Paraplegia 1965;3:199-202.[Google Scholar]
Kiwerski J. Recovery of simple hand function in tetraplegia patients following transfer of the musculo-cutaneous nerve into the median nerve. Paraplegia 1982;20:242-7.[Google Scholar]
Bertelli JA, Tacca CP, Ghizoni MF, Kechele PR, Santos MA. Transfer of supinator motor branches to the posterior interosseous nerve to reconstruct thumb and finger extension in tetraplegia: Case report. J Hand Surg Am 2010;35:1647-51.[Google Scholar]
Bertelli JA, Ghizoni MF, Tacca CP. Transfer of the teres minor motor branch for triceps reinnervation in tetraplegia. J Neurosurg 2011;114:1457-60.[Google Scholar]
Brown JM. Nerve transfers in tetraplegia I: Background and technique. Surg Neurol Int 2011;2:121.[Google Scholar]
Fridén J, Gohritz A. Brachialis-to-extensor carpi radialis longus selective nerve transfer to restore wrist extension in tetraplegia: Case report. J Hand Surg Am 2012;37:1606-8.[Google Scholar]
Mackinnon SE, Yee A, Ray WZ. Nerve transfers for the restoration of hand function after spinal cord injury. J Neurosurg 2012;117:176-85.[Google Scholar]
Bertelli JA, Ghizoni MF. Transfer of nerve branch to the brachialis to reconstruct elbow extension in incomplete tetraplegia: Case report. J Hand Surg Am 2012;37:1990-3.[Google Scholar]
Bertelli JA, Mendes Lehm VL, Tacca CP, Winkelmann Duarte EC, Ghizoni MF, Duarte H, et al. Transfer of the distal terminal motor branch of the extensor carpi radialis brevis to the nerve of the flexor pollicis longus: An anatomic study and clinical application in a tetraplegic patient. Neurosurgery 2012;70:1011-6.[Google Scholar]
Bertelli JA, Ghizoni MF. Single-stage surgery combining nerve and tendon transfers for bilateral upper limb reconstruction in a tetraplegic patient: Case report. J Hand Surg Am 2013;38:1366-9.[Google Scholar]
van Zyl N, Hahn JB, Cooper CA, Weymouth MD, Flood SJ, Galea MP, et al. Upper limb reinnervation in C6 tetraplegia using a triple nerve transfer: Case report. J Hand Surg Am 2014;39:1779-83.[Google Scholar]
Bertelli JA, Ghizoni MF. Nerve transfers for elbow and finger extension reconstruction in midcervical spinal cord injuries. J Neurosurg 2015;122:121-7.[Google Scholar]
Fox IK, Davidge KM, Novak CB, Hoben G, Kahn LC, Juknis N, et al. Use of peripheral nerve transfers in tetraplegia: Evaluation of feasibility and morbidity. Hand (N Y) 2015;10:60-7.[Google Scholar]
Fox IK, Davidge KM, Novak CB, Hoben G, Kahn LC, Juknis N, et al. Nerve transfers to restore upper extremity function in cervical spinal cord injury: Update and preliminary outcomes. Plast Reconstr Surg 2015;136:780-92.[Google Scholar]
Hawasli AH, Chang J, Reynolds MR, Ray WZ. Transfer of the brachialis to the anterior interosseous nerve as a treatment strategy for cervical spinal cord injury: Technical note. Global Spine J 2015;5:110-7.[Google Scholar]
Available from: https://www.academia.edu/8407891/Reconstruction_of_the_upper_limb_in_tetraplegia. [Last accessed on 2018 Dec 02].[Google Scholar]
IFSSH Scientific Committee on Nerve-Spinal Cord Injury Report: Update on Hand Surgery in Tetraplegia; 2014.[Google Scholar]
Curtin CM, Wagner JP, Gater DR, Chung KC. Opinions on the treatment of people with tetraplegia: Contrasting perceptions of physiatrists and hand surgeons. J Spinal Cord Med 2007;30:256-62.[Google Scholar]
Curtin CM, Hayward RA, Kim HM, Gater DR, Chung KC. Physician perceptions of upper extremity reconstruction for the person with tetraplegia. J Hand Surg Am 2005;30:87-93.[Google Scholar]
Wagner JP, Curtin CM, Gater DR, Chung KC. Perceptions of people with tetraplegia regarding surgery to improve upper-extremity function. J Hand Surg Am 2007;32:483-90.[Google Scholar]